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Cellular and Molecular Life Sciences

, Volume 64, Issue 2, pp 230–243 | Cite as

Autotaxin (NPP-2) in the brain: cell type-specific expression and regulation during development and after neurotrauma

  • N. E. SavaskanEmail author
  • L. Rocha
  • M. R. Kotter
  • A. Baer
  • G. Lubec
  • L. A. van Meeteren
  • Y. Kishi
  • J. Aoki
  • W. H. Moolenaar
  • R. Nitsch
  • A. U. BräuerEmail author
Research Article

Abstract.

Autotaxin is a secreted cell motility-stimulating exo-phosphodiesterase with lysophospholipase D activity that generates bioactive lysophosphatidic acid. Lysophosphatidic acid has been implicated in various neural cell functions such as neurite remodeling, demyelination, survival and inhibition of axon growth. Here, we report on the in vivo expression of autotaxin in the brain during development and following neurotrauma. We found that autotaxin is expressed in the proliferating subventricular and choroid plexus epithelium during embryonic development. After birth, autotaxin is mainly found in white matter areas in the central nervous system. In the adult brain, autotaxin is solely expressed in leptomeningeal cells and oligodendrocyte precursor cells. Following neurotrauma, autotaxin is strongly up-regulated in reactive astrocytes adjacent to the lesion. The present study revealed the cellular distribution of autotaxin in the developing and lesioned brain and implies a function of autotaxin in oligodendrocyte precursor cells and brain injuries.

Keywords.

LPA signaling S1P axonal growth and regeneration hippocampus brain development G protein-coupled receptors myelination oligodendrocyte precursor cells 

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Copyright information

© Birkhäuser Verlag, Basel 2007

Authors and Affiliations

  • N. E. Savaskan
    • 1
    Email author
  • L. Rocha
    • 2
  • M. R. Kotter
    • 3
  • A. Baer
    • 3
  • G. Lubec
    • 3
  • L. A. van Meeteren
    • 1
  • Y. Kishi
    • 4
  • J. Aoki
    • 4
  • W. H. Moolenaar
    • 1
  • R. Nitsch
    • 2
  • A. U. Bräuer
    • 2
    Email author
  1. 1.Division of Cellular BiochemistryThe Netherlands Cancer InstituteAmsterdamThe Netherlands
  2. 2.Institute for Cell Biology and Neurobiology, Center for AnatomyCharité – Universitätsmedizin BerlinBerlinGermany
  3. 3.Department of Neurosurgery, BrainProt Neuroprotection-Neuroregeneration LaboratoryAKH/Medical University ViennaViennaAustria
  4. 4.Graduate School of Pharmaceutical SciencesThe University of Tokyo, PRESTO7, Japan Science and Technology AgencyTokyoJapan

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