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Cellular and Molecular Life Sciences CMLS

, Volume 63, Issue 23, pp 2847–2858 | Cite as

Chronic quercetin exposure affects fatty acid catabolism in rat lung

  • V. C. J. de Boer
  • E. M. van Schothorst
  • A. A. Dihal
  • H. van der Woude
  • I. C. W. Arts
  • I. M. C. M. Rietjens
  • P. C. H. Hollman
  • J. KeijerEmail author
Research Article

Abstract.

Dietary quercetin intake is suggested to be health promoting, but this assumption is mainly based on mechanistic studies performed in vitro. Previously, we identified rat lung as a quercetin target tissue. To assess relevant in vivo health effects of quercetin, we analyzed mechanisms of effect in rat lungs of a chronic (41 weeks) 1% quercetin diet using whole genome microarrays. We show here that fatty acid catabolism pathways, like beta-oxidation and ketogenesis, are up-regulated by the long-term quercetin intervention. Up-regulation of genes (Hmgcs2, Ech1, Acox1, Pcca, Lpl and Acaa2) was verified and confirmed by quantitative real time PCR. In addition, free fatty acid levels were decreased in rats fed the quercetin diet, confirming that quercetin affects fatty acid catabolism. This in vivo study demonstrates for the first time that fatty acid catabolism is a relevant process that is affected in rats by chronic dietary quercetin.

Keywords.

Quercetin microarray fatty acid metabolism nutrigenomics flavonoids polyphenols 

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Copyright information

© Birkhäuser Verlag, Basel 2006

Authors and Affiliations

  • V. C. J. de Boer
    • 1
    • 2
  • E. M. van Schothorst
    • 1
  • A. A. Dihal
    • 2
    • 3
  • H. van der Woude
    • 2
  • I. C. W. Arts
    • 1
  • I. M. C. M. Rietjens
    • 2
  • P. C. H. Hollman
    • 1
  • J. Keijer
    • 1
    Email author
  1. 1.RIKILT-Institute of Food SafetyWageningen University and Research CenterWageningenThe Netherlands
  2. 2.Division of ToxicologyWageningen UniversityWageningenThe Netherlands
  3. 3.TNO Quality of LifeBusiness Unit BioSciencesZeistThe Netherlands

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