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The gateway to transcription: identifying, characterizing and understanding promoters in the eukaryotic genome

  • N. D. Heintzman
  • B. RenEmail author
Review

Abstract.

Eukaryotic transcriptional regulation requires the integration of complex signals by the transcriptional promoter. Distinct sequence elements, characteristic chromatin modifications and coordinated protein-DNA interactions at these sequences constitute a transcriptional regulatory code that remains poorly understood today. Here, we review recent experimental and computational advances that have enabled the identification and analysis of transcriptional promoters on an unprecedented scale, laying a foundation for systematic determination of the transcriptional regulatory networks in eukaryotic cells. The knowledge gained from these large-scale investigations has challenged some conventional concepts of promoter structure and function, and provided valuable insights into the complex gene regulatory mechanisms in a variety of organisms.

Keywords.

Promoter transcriptional regulation ChIP-chip epigenetics regulatory networks 

Copyright information

© Birkhäuser Verlag, Basel 2006

Authors and Affiliations

  1. 1.Ludwig Institute for Cancer Research, Department of Cellular and Molecular MedicineUniversity of California, San Diego School of MedicineLa JollaUSA
  2. 2.Ludwig Institute for Cancer Research, Department of Cellular and Molecular MedicineUniversity of California, Biomedical Sciences Graduate ProgramLa JollaUSA

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