Signaling in the Chemosensory Systems
- 171 Downloads
Of all five senses, olfaction is the most complex molecular mechanism, as it comprises hundreds of receptor proteins enabling it to detect and discriminate thousands of odorants. Until lately, the understanding of this highly sophisticated sensory neuronal pathway has been rather sketchy. The sequencing of the human genome and the consequent advent of new genomic tools have opened new opportunities to better understand this multifaceted biological system. Here, we present the relevant progresses made in the last decade and highlight the possible genetic mechanisms of human olfactory variability.
Keywords.Olfactory receptors congenital general anosmia specific anosmia SNPs pseudogenes threshold sensitivity
Unable to display preview. Download preview PDF.