Cellular and Molecular Life Sciences CMLS

, Volume 63, Issue 13, pp 1485–1493 | Cite as

Signaling in the Chemosensory Systems

Variations in the human olfactory receptor pathway
  • I. Menashe
  • D. LancetEmail author
Multi-author Review


Of all five senses, olfaction is the most complex molecular mechanism, as it comprises hundreds of receptor proteins enabling it to detect and discriminate thousands of odorants. Until lately, the understanding of this highly sophisticated sensory neuronal pathway has been rather sketchy. The sequencing of the human genome and the consequent advent of new genomic tools have opened new opportunities to better understand this multifaceted biological system. Here, we present the relevant progresses made in the last decade and highlight the possible genetic mechanisms of human olfactory variability.


Olfactory receptors congenital general anosmia specific anosmia SNPs pseudogenes threshold sensitivity 


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Copyright information

© Birkhäuser Verlag, Basel 2006

Authors and Affiliations

  1. 1.Department of Molecular Genetics and the Crown Human Genome CenterWeizmann Institute of ScienceRehovotIsrael

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