Cellular and Molecular Life Sciences CMLS

, Volume 63, Issue 14, pp 1632–1641 | Cite as

Tribbles: novel regulators of cell function; evolutionary aspects

  • Z. Hegedus
  • A. Czibula
  • E. Kiss-TothEmail author


Identification of rate-limiting steps or components of intracellular second messenger systems holds promise to effectively interfere with these pathways under pathological conditions. The emerging literature on a recently identified family of signalling regulator proteins, called tribbles gives interesting clues for how these proteins seem to link several ‘independent’ signal processing systems together. Via their unique way of action, tribbles co-ordinate the activation and suppression of the various interacting signalling pathways and therefore appear to be key in determining cell fate while responding to environmental challenges. This review summarises our current understanding of tribbles function and also provides an evolutionary perspective on the various tribbles genes.


Signal transduction tribbles MAPK Akt ATF4 regulation of signalling scaffolds 


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Copyright information

© Birkhäuser Verlag, Basel 2006

Authors and Affiliations

  1. 1.Biological Research CentreBioinformatics GroupSzegedHungary
  2. 2.Biological Research CentreMolecular Humangenetics Group, Institute of GeneticsSzegedHungary
  3. 3.Cardiovascular Research Unit, Division of Clinical Sciences (North)University of Sheffield, Northern General HospitalSheffieldUK

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