Cellular and Molecular Life Sciences CMLS

, Volume 63, Issue 6, pp 686–697 | Cite as

Galectin-7

Review

Abstract.

Galectins are a family of animal lectins with an affinity for β-galactosides. They are differentially expressed by various tissues and appear to be functionally multivalent, exerting a wide range of biological activities both during development and in adult tissue. Galectin-7, a member of this family, contributes to different events associated with the differentiation and development of pluristratified epithelia. It is also associated with epithelial cell migration, which plays a crucial role in the re-epithelialization process of corneal or epidermal wounds. In addition, recent evidence indicates that galectin-7, designated as the product of the p53-induced gene 1 (PIG1), is a regulator of apoptosis through JNK activation and mitochondrial cytochrome c release. Defects in apoptosis constitute one of the major hallmarks of human cancers, and galectin-7 can act as either a positive or a negative regulatory factor in tumour development, depending on the histological type of the tumour.

Key words.

Galectin-7 epithelium migration apoptosis carcinogenesis 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Birkhäuser Verlag, Basel 2006

Authors and Affiliations

  1. 1.Laboratory of Histology, and Laboratory of Anatomy, Faculty of Medicine and PharmacyUniversity of Mons-Hainaut (UMH)MonsBelgium
  2. 2.Laboratory of Toxicology – Institute of PharmacyFree University of Brussels (ULB)BrusselsBelgium

Personalised recommendations