Cellular and Molecular Life Sciences CMLS

, Volume 62, Issue 24, pp 2985–3001 | Cite as

Functionality of the TRPV subfamily of TRP ion channels: add mechano-TRP and osmo-TRP to the lexicon!

  • W. Liedtke
  • C. KimEmail author


Transient receptor potential (TRP) ion channels have been identified as cellular sensors responding to diverse external and internal stimuli. This review will cover the TRPV subfamily that comprises vertebrate and invertebrate members. The six mammalian TRPV channels were demonstrated to function in thermosensation, mechanosensation, osmosensation and Ca2+ uptake. Invertebrate TRPV channels, five in Caenorhabditis elegans and two in Drosophila, have been shown to play a role in mechanosensation, such as hearing and proprioception in Drosophila and nose touch in C. elegans, and in the response to osmotic and chemical stimuli in C. elegans. We will focus here on the role that TRPV ion channels play in mechanosensation and a related sensory (sub-)modality, osmosensation.

Key words.

TRP TRPV mechano-TRP osmo-TRP C. elegans Drosophila TRPV4 OSM-9 OCR-2 NAN IAV 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Birkhäuser Verlag, Basel 2005

Authors and Affiliations

  1. 1.Center for Translational Neuroscience, Department of Neurobiology, Department of Medicine/Division of NeurologyDuke University Medical CenterDurhamUSA
  2. 2.Hormone Research Center, School of Biological SciencesChonnam National UniversityKwangJu-SiSouth Korea

Personalised recommendations