Cellular and Molecular Life Sciences CMLS

, Volume 62, Issue 16, pp 1826–1838 | Cite as

The HERC proteins: functional and evolutionary insights



HERC proteins are defined as containing both HECT and RCC1-like domains in their amino acid sequences. Six HERC genes have turned up in the human genome which encode two different sorts of polypeptides: while the small HERC proteins possess little more than the two aforementioned domains, the large ones are giant proteins with a plethora of potentially important regions. It is now almost 10 years since the discovery of the first family member and information is starting to accumulate pointing to a general role for these proteins as ubiquitin ligases involved in membrane-trafficking events. In this review, the available data on these six members are discussed, together with an account of their evolution.

Key words.

HERC proteins RCC1-like domain HECT domain ubiquitin ligase 


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Copyright information

© Birkhäuser Verlag, Basel 2005

Authors and Affiliations

  1. 1.Departament de Ciències Fisiològiques II, IDIBELL, Campus de Bellvitge, L’Hospitalet de LlobregatUniversitat de BarcelonaBarcelonaSpain

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