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Cellular and Molecular Life Sciences CMLS

, Volume 62, Issue 13, pp 1409–1417 | Cite as

Disordered RNA chaperone proteins: from functions to disease

  • R. Ivanyi-Nagy
  • L. Davidovic
  • E. W. Khandjian
  • J.-L. DarlixEmail author
Visions & Reflections

Abstract.

RNA chaperones are ubiquitous proteins that play pivotal roles in cellular RNA metabolism and RNA virus replication. Here we propose that they act by organizing complex and highly dynamic networks of RNA-RNA, RNA-protein and protein-protein interactions. How this is achieved and how their malfunction may lead to disease will be discussed through the examples of human immunodeficiency virus type 1 nucleocapsid protein (NCp7), the fragile X mental retardation protein and the prion protein.

Key words.

Intrinsically unstructured proteins RNA-binding proteins RNA chaperones human immunodeficiency virus NCp7 fragile X mental retardation FMRP prion diseases 

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Copyright information

© Birkhäuser Verlag, Basel 2005

Authors and Affiliations

  • R. Ivanyi-Nagy
    • 1
  • L. Davidovic
    • 2
  • E. W. Khandjian
    • 2
  • J.-L. Darlix
    • 1
    Email author
  1. 1.Unité de Virologie Humaine (412)Ecole Normale Supérieure de Lyon et Institut National de la Santé et de la Recherche Médicale, IFR 128LyonFrance
  2. 2.Unité de Recherche en Génétique Humaine et Moléculaire, le CHUQ-Hôpital St-François d’AssiseUniversité LavalQuébecCanada

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