Leptin receptor action and mechanisms of leptin resistance

  • H. Münzberg
  • M. Björnholm
  • S. H. Bates
  • M. G. MyersJr

Abstract.

The adipose tissue-derived hormone leptin regulates energy balance and neuroendocrine function. Resistance to the appetite-suppressing effects of leptin is associated with common forms of obesity. Here, we review the mechanisms by which leptin activates intracellular signals and the roles that these signals play in leptin action in vivo. Furthermore, we discuss potential mechanisms of leptin resistance, specifically focusing on data regarding the neuroanatomical locus of leptin resistance and potential mechanisms by which expression of the suppressor of cytokine signaling-3 may impair leptin action.

Key words.

Leptin obesity SOCS3 signaling arcuate nucleus hypothalamus 

Copyright information

© Birkhäuser Verlag, Basel 2005

Authors and Affiliations

  • H. Münzberg
    • 1
  • M. Björnholm
    • 1
  • S. H. Bates
    • 1
  • M. G. MyersJr
    • 1
  1. 1.Division of Metabolism, Endocrinology and Diabetes, Departments of Internal Medicine and Molecular and PhysiologyUniversity of Michigan Medical SchoolAnn ArborUSA

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