Cellular and Molecular Life Sciences CMLS

, Volume 62, Issue 3, pp 320–343

The role of insulin and IGF-1 signaling in longevity


DOI: 10.1007/s00018-004-4297-y

Cite this article as:
Katic, M. & Kahn, C.R. CMLS, Cell. Mol. Life Sci. (2005) 62: 320. doi:10.1007/s00018-004-4297-y


There are many theories of aging and parameters that influence lifespan, including genetic instability, telomerase activity and oxidative stress. The role of caloric restriction, metabolism and insulin and insulin-like growth factor-1 signaling in the process of aging is especially well conserved throughout evolution. These latter factors interact with each other, the former factors and histone deacetylases of the SIR family in a complex interaction to influence lifespan.

Key words.

Aging lifespan genetic instability telomerase oxidative stress superoxide dismutase oxidants antioxidants reactive oxygen species gluthatione thioredoxin metabolism calorie restriction insulin IGF-1 growth hormone signaling Sir FOXO p66 klotho animal models S. cerevisiae C. elegans D. melanogaster mouse knockout human syndrome Ames Dwarf Snell Dwarf FIRKO 

Copyright information

© Birkhäuser Verlag, Basel 2005

Authors and Affiliations

  1. 1.Joslin Diabetes Center and Department of Medicine Harvard Medical SchoolBostonUSA

Personalised recommendations