Cellular and Molecular Life Sciences CMLS

, Volume 62, Issue 3, pp 320–343 | Cite as

The role of insulin and IGF-1 signaling in longevity

  • M. Katic
  • C. R. Kahn


There are many theories of aging and parameters that influence lifespan, including genetic instability, telomerase activity and oxidative stress. The role of caloric restriction, metabolism and insulin and insulin-like growth factor-1 signaling in the process of aging is especially well conserved throughout evolution. These latter factors interact with each other, the former factors and histone deacetylases of the SIR family in a complex interaction to influence lifespan.

Key words.

Aging lifespan genetic instability telomerase oxidative stress superoxide dismutase oxidants antioxidants reactive oxygen species gluthatione thioredoxin metabolism calorie restriction insulin IGF-1 growth hormone signaling Sir FOXO p66 klotho animal models S. cerevisiae C. elegans D. melanogaster mouse knockout human syndrome Ames Dwarf Snell Dwarf FIRKO 


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Copyright information

© Birkhäuser Verlag, Basel 2005

Authors and Affiliations

  1. 1.Joslin Diabetes Center and Department of Medicine Harvard Medical SchoolBostonUSA

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