Cellular and Molecular Life Sciences CMLS

, Volume 62, Issue 3, pp 320–343 | Cite as

The role of insulin and IGF-1 signaling in longevity

Abstract.

There are many theories of aging and parameters that influence lifespan, including genetic instability, telomerase activity and oxidative stress. The role of caloric restriction, metabolism and insulin and insulin-like growth factor-1 signaling in the process of aging is especially well conserved throughout evolution. These latter factors interact with each other, the former factors and histone deacetylases of the SIR family in a complex interaction to influence lifespan.

Key words.

Aging lifespan genetic instability telomerase oxidative stress superoxide dismutase oxidants antioxidants reactive oxygen species gluthatione thioredoxin metabolism calorie restriction insulin IGF-1 growth hormone signaling Sir FOXO p66 klotho animal models S. cerevisiae C. elegans D. melanogaster mouse knockout human syndrome Ames Dwarf Snell Dwarf FIRKO 

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Copyright information

© Birkhäuser Verlag, Basel 2005

Authors and Affiliations

  1. 1.Joslin Diabetes Center and Department of Medicine Harvard Medical SchoolBostonUSA

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