Oncogenic protein tyrosine kinases
- Cite this article as:
- Santoro, M., Carlomagno, F., Melillo, R.M. et al. CMLS, Cell. Mol. Life Sci. (2004) 61: 2954. doi:10.1007/s00018-004-4276-8
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RET is the receptor for glial-derived neurotrophic factor growth factors. It is a paradigm of a single gene that causes different types of human cancer when targeted by different genetic alterations. Like other receptor tyrosine kinases, once activated, RET recruits a variety of signaling molecules that mediate biological responses. Here we review data on the signaling pathways that lead to RET-mediated cell transformation and recent evidence that manipulation of RET holds promise for thyroid cancer treatment.