Cellular and Molecular Life Sciences CMLS

, Volume 61, Issue 23, pp 2924–2931

Oncogenic protein tyrosine kinases

Kit as a human oncogenic tyrosine kinase
Multi-author Review

Abstract.

Signals through Kit receptor tyrosine kinase are essential for development of erythrocytes, melanocytes, germ cells, mast cells and interstitial cells of Cajal (ICCs). Mice and rats with a double gene dose of loss-of-function mutations of Kit show depletion of these cells. Although human homozygotes with loss-of-function mutations of Kit have not been reported, gain-of-function mutations of Kit result in development of tumors from mast cells, germ cells and ICCs in humans. The ICC tumors are called gastrointestinal stromal tumors (GISTs), and GISTs are a good target for the Kit inhibitor imatinib mesylate. The interrelationship between the type of Kit gain-of-function mutations and the therapeutic effect of imatinib mesylate has been well characterized in GISTs. Kit is interesting from both a biological and clinical view-point.

Key words.

Kit KitL mast cell germ cell interstitial cell of Cajal imatinib mesylate 

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Copyright information

© Birkhäuser Verlag, Basel 2004

Authors and Affiliations

  1. 1.Shionogi Pharmaceutical CompanyOsakaJapan
  2. 2.Department of Pathology, Medical School/Graduate School of Frontier BioscienceOsaka UniversityOsakaJapan

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