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Cellular and Molecular Life Sciences CMLS

, Volume 61, Issue 10, pp 1157–1166 | Cite as

Phylogenetic origin of LI-cadherin revealed by protein and gene structure analysis

  • R. Jung
  • M. W. Wendeler
  • M. Danevad
  • H. Himmelbauer
  • R. Geßner
Research Article

Abstract

The intestine specific LI-cadherin differs in its overall structure from classical and desmosomal cadherins by the presence of seven instead of five cadherin repeats and a short cytoplasmic domain. Despite the low sequence similarity, a comparative protein structure analysis revealed that LI-cadherin may have originated from a five-repeat predecessor cadherin by a duplication of the first two aminoterminal repeats. To test this hypothesis, we cloned the murine LI-cadherin gene and compared its structure to that of other cadherins. The intron-exon organization, including the intron positions and phases, is perfectly conserved between repeats 3–7 of LI-cadherin and 1–5 of classical cadherins. Moreover, the genomic structure of the repeats 1–2 and 3–4 is identical for LI-cadherin and highly similar to that of the repeats 1–2 of classical cadherins. These findings strengthen our assumption that LI-cadherin originated from an ancestral cadherin with five domains by a partial gene duplication event.

LI-cadherin cadherin evolution partial gene duplication cadherin repeat phylogeny gene structure 

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Copyright information

© Birkhäuser-Verlag Basel 2004

Authors and Affiliations

  • R. Jung
    • 1
    • 3
  • M. W. Wendeler
    • 1
  • M. Danevad
    • 1
  • H. Himmelbauer
    • 2
  • R. Geßner
    • 1
  1. 1.Institute of Laboratory Medicine and Biochemistry, Virchow-Hospital of Charité Medical SchoolHumboldt University of BerlinBerlinGermany
  2. 2.Max-Planck-Institute of Molecular GeneticsBerlinGermany
  3. 3.Schering AGBerlinGermany

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