Cellular and Molecular Life Sciences CMLS

, Volume 61, Issue 10, pp 1123–1142 | Cite as

Computational approaches to structural and functional analysis of plastocyanin and other blue copper proteins

  • F. De Rienzo
  • R. R. Gabdoulline
  • R. C. Wade
  • M. Sola
  • M. C. Menziani

Abstract

Computational techniques are becoming increasingly important in structural and functional biology, in particular as tools to aid the interpretation of experimental results and the design of new systems. This review reports on recent studies employing a variety of computational approaches to unravel the microscopic details of the structure-function relationships in plastocyanin and other proteins belonging to the blue copper superfamily. Aspects covered include protein recognition, electron transfer and protein-solvent interaction properties of the blue copper protein family. The relevance of integrating diverse computational approaches to address the analysis of a complex protein system, such as a cupredoxin metalloprotein, is emphasized.

Plastocyanin blue copper proteins electron transfer protein-protein association structure-function relationship QSAR computational analysis 

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Copyright information

© Birkhäuser-Verlag Basel 2004

Authors and Affiliations

  • F. De Rienzo
    • 1
    • 2
  • R. R. Gabdoulline
    • 3
  • R. C. Wade
    • 3
  • M. Sola
    • 1
    • 2
  • M. C. Menziani
    • 1
  1. 1.Chemistry DepartmentUniversity of Modena and Reggio EmiliaModenaItaly
  2. 2.INFM National Center on nanoStructures and bioSystems at Surfaces (S3)ModenaItaly
  3. 3.EML Research GmbH, Villa BoschHeidelbergGermany

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