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Cellular and Molecular Life Sciences CMLS

, Volume 61, Issue 7–8, pp 843–856 | Cite as

Snake venom thrombin-like enzymes: from reptilase to now

  • H. C. CastroEmail author
  • R. B. Zingali
  • M. G. Albuquerque
  • M. Pujol-Luz
  • C. R. Rodrigues
Review

Abstract

The snake venom thrombin-like enzymes (SVTLEs) comprise a number of serine proteases functionally and structurally related to thrombin. Until recently, only nine complete sequences of this subgroup of the serine protease family were known. Over the past 5 years, the primary structure of several SVTLEs has been characterized, and now this family includes several members. Of particular interest is their possible use in pathologies such as thrombosis. The aim of the present review is to summarize the state of the art concerning the evolutionary, structural and biological features of the SVTLEs.

Snake venom thrombin fibrinogen platelets primary sequence serine protease 

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Copyright information

© Birkhäuser-Verlag Basel 2004

Authors and Affiliations

  • H. C. Castro
    • 1
    Email author
  • R. B. Zingali
    • 2
  • M. G. Albuquerque
    • 3
  • M. Pujol-Luz
    • 1
  • C. R. Rodrigues
    • 4
  1. 1.Laboratório de Bioquímica e Modelagem Molecular (LaBioMol), 3° andar, Departamento de Biologia Celular e Molecular, IB-CEGUniversidade Federal FluminenseRio de JaneiroBrazil
  2. 2.Laboratório de Hemostase e Veneno (LabHemoVen), Departamento de Bioquímica Médica, ICB-CCSUniversidade Federal do Rio de JaneiroRio de JaneiroBrazil
  3. 3.Laboratório de Modelagem Molecular (LabMMol), Departamento de Química Orgânica, IQ-CCMNUniversidade Federal do Rio de JaneiroRio de JaneiroBrazil
  4. 4.Laboratório de Modelagem Molecular e QSAR (ModMolQSAR), Faculdade de FarmáciaUniversidade Federal do Rio de JaneiroRio de JaneiroBrazil

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