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Cellular and Molecular Life Sciences CMLS

, Volume 61, Issue 1, pp 19–34 | Cite as

Enzymology of NAD+ homeostasis in man

  • G. MagniEmail author
  • A. Amici
  • M. Emanuelli
  • G. Orsomando
  • N. Raffaelli
  • S. Ruggieri
Review

Abstract

This review describes the enzymes involved in human pyridine nucleotide metabolism starting with a detailed consideration of their major kinetic, molecular and structural properties. The presentation encompasses all the reactions starting from the de novo pyridine ring formation and leading to nicotinamide adenine dinucleotide (NAD+) synthesis and utilization. The regulation of NAD+ homeostasis with respect to the physiological role played by the enzymes both utilizing NAD+ through the nonredox NAD+-dependent reactions and catalyzing the recycling of the common product, nicotinamide, is discussed. The salient features of other enzymes such as NAD+ pyrophosphatase, nicotinamide mononucleotide 5′-nucleotidase, nicotinamide riboside kinase and nicotinamide riboside phosphorylase, described under ‘miscellaneous’, are likewise presented.

NAD+ homeostasis pyridine nucleotides structure biology recombinant enzymes chromatin expression 

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Copyright information

© Birkhäuser-Verlag Basel 2004

Authors and Affiliations

  • G. Magni
    • 1
    Email author
  • A. Amici
    • 1
  • M. Emanuelli
    • 1
  • G. Orsomando
    • 1
  • N. Raffaelli
    • 1
  • S. Ruggieri
    • 1
  1. 1.Istituto di Biotecnologie BiochimicheUniversità Politecnica delle MarcheAnconaItaly

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