Cellular and Molecular Life Sciences CMLS

, Volume 60, Issue 11, pp 2465–2482 | Cite as

Receptor and nonreceptor protein tyrosine phosphatases in the nervous system

  • S. PaulEmail author
  • P. J. Lombroso


Protein tyrosine phosphatases (PTPs) have emerged as a new class of signaling molecules that play important roles in the development and function of the central nervous system. They include both tyrosine-specific and dual-specific phosphatases. Based on their cellular localization they are also classified as receptor-like or intracellular PTP. However, the intracellular mechanisms by which these PTPs regulate cellular signaling pathways are not well understood. Evidence gathered to date provides some insight into the physiological function of these PTPs in the nervous system. In this review, we outline what is currently known about the functional role of PTPs expressed in the brain.

Receptor PTPs intracellular tyrosine phosphatase dual-specificity phosphatases nervous system intracellular signaling 


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Copyright information

© Birkhäuser-Verlag Basel 2003

Authors and Affiliations

  1. 1.From the Child Study CenterYale University School of MedicineConnecticut

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