Cellular and Molecular Life Sciences CMLS

, Volume 60, Issue 9, pp 1903–1922

Immunology and functional genomics of Behçet's disease

  • M. Zierhut
  • N. Mizuki
  • S. Ohno
  • H. Inoko
  • A. Gül
  • K. Onoé
  • E. Isogai
Review Paper

Abstract

Behçet's disease (BD) is a multisystemic inflammatory disorder. Although the cause and pathogenesis of BD are still unclear, there is evidence for genetic, immunologic and infectious factors at the onset or in the course of BD. This review focusses on the functional genomics and immunology of BD. HLA-B51 is the major disease susceptibility gene locus in BD. An increased number of γδ T cells in the peripheral blood and in the involved tissues have been reported. However, the T cells at the sites of inflammation appear to be a phenotypically distinct subset. There is also a significant γδ T cell proliferative response to mycobacterial 65-kDa heat shock protein peptides. Homologous peptides derived from the human 60-kDa heat shock protein were observed in BD patients. There is evidence that natural killer T cells may also play a role in BD.

Behçet's disease vasculitis uveitis experimental autoimmune uveitis HLA streptococcus herpes simplex virus heat shock protein T cells NK-T-cells neutrophils cytokines endothelial dysfunction coagulation and fibrinolytic pathway abnormalities 

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Copyright information

© Birkhäuser-Verlag Basel 2003

Authors and Affiliations

  • M. Zierhut
    • 1
  • N. Mizuki
    • 2
    • 3
  • S. Ohno
    • 4
  • H. Inoko
    • 3
  • A. Gül
    • 5
  • K. Onoé
    • 6
  • E. Isogai
    • 7
  1. 1.Department of OphthalmologyUniversity of TuebingenTuebingen
  2. 2.Department of OphthalmologyYokohama City University School of MedicineYokohoma
  3. 3.Department of Genetic InformationDivision of Molecular Life Science, Tokai University School of MedicineBohseidaiIsehara
  4. 4.Department of Ophthalmology and Visual SciencesHokkaido University Graduate School of MedicineSapporoHokkaido
  5. 5.Division of Rheumatology, Department of Internal MedicineIstanbul Faculty of Medicine, Istanbul UniversityIstanbul
  6. 6.Division of ImmunobiologyInstitute for Genetic Medicine, Hokkaido UniversitySapporo
  7. 7.Department of Preventive DentistryHealth Sciences University of HokkaidoHokkaido

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