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Cellular and Molecular Life Sciences CMLS

, Volume 60, Issue 4, pp 688–700 | Cite as

Relaxin: a pregnancy hormone as central player of body fluid and circulation homeostasis

  • T. Dschietzig
  • K. Stangl
Review

Abstract.

The peptide relaxin has long been regarded as an important hormone of pregnancy, contributing to changes in connective tissue composition as well as to regulation of implantation, myometrial activity and labor. On the other hand, the astonishing pleiotropy of this hormone escaped scientific awareness. This review focuses on new facets of relaxin, including its antifibrotic effects, its role in the control of pituitary hormone release, its vasodilator and pro-angiogenic properties and its versatile myocardial actions. Recent progress in understanding relaxin's receptor and signaling mechanisms is also highlighted. The peptide will be characterized as potential regulator of body fluid and circulation homeostasis.

Key words. cAMP; G-protein receptor; MAP kinase; myocardium; nitric oxide; peptide; tyrosine kinase. 

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Copyright information

© Birkhäuser Verlag, 2003

Authors and Affiliations

  • T. Dschietzig
    • 1
  • K. Stangl
    • 1
  1. 1.Medizinische Klinik mit Schwerpunkt Kardiologie, Angiologie und Pulmologie, Universitätsklinikum Charité (Campus Mitte), Schumannstr. 20/21, 10117 Berlin (Germany), Fax: + 49 30 450 513 932, e-mail: karl.stangl@charite.deDE

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