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Cellular and Molecular Life Sciences CMLS

, Volume 59, Issue 3, pp 456–462 | Cite as

Novel regulation and function of Src tyrosine kinase

  • Y.-C. Ma
  • X.-Y. Huang

Abstract.

Src tyrosine kinase is a critical signal transducer that modulates a wide variety of cellular functions. Misregulation of Src leads to cell transformation and cancer. Heterotrimeric guanine-nucleotide-binding proteins (G proteins) are another group of signaling molecules that transduce signals from cell-surface receptors to generate physiological responses. Recently, it was discovered that Gαs and Gαi could directly stimulate Src family tyrosine kinase activity. This novel regulation of Src tyrosine kinase by G proteins provides insights into the adenylyl cyclase-independent signaling mechanisms involved in ligand-induced receptor desensitization, internalization and other physiological processes.

Key words. Src tyrosine kinase; G protein; adenylyl cyclase; receptor desensitization; receptor internalization. 

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Copyright information

© Birkhäuser Verlag, 2002

Authors and Affiliations

  • Y.-C. Ma
    • 1
  • X.-Y. Huang
    • 1
  1. 1.Department of Physiology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021 (USA), Fax: + 1 212 746 8690, e-mail: xyhuang@med.cornell.eduUS

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