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Cellular and Molecular Life Sciences CMLS

, Volume 59, Issue 1, pp 156–170 | Cite as

The multifaceted Paneth cell

  • E.M. Porter
  • C.L. Bevins
  • D. Ghosh
  • T. Ganz

Abstract.

Paneth cells (PCs) were described over a century ago as granulated cells located at the base of small intestinal crypts, the 'crypts of Lieberkühn.' Various histochemical staining procedures were developed that identified PCs based on their distinctive granule staining pattern. Early on, PCs were proposed to perform a specialized function other than absorption of digested nutrients, the predominant task of the small intestinal epithelium. Since then, many constituents of the PC granules have been biochemically characterized. The presence of various granule-associated antimicrobial substances and their release upon microbial challenge suggest that PCs function as specialized defense cells in the small intestine. Altered resistance to microbial infection in animal models with disrupted or augmented PC function provides further support for the host defense role of PCs. Other PC components suggest that PCs may also participate in the regulation of lumenal ionic composition, crypt development, digestion, and intestinal inflammation.

Key words. Innate immunity; pancreas; inflammatory bowel disease; antimicrobial peptide; cytokine; matrilysin; trypsin. 

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Copyright information

© Birkhäuser Verlag, 2002

Authors and Affiliations

  • E.M. Porter
    • 1
  • C.L. Bevins
    • 3
  • D. Ghosh
    • 3
  • T. Ganz
    • 2
  1. 1.Department of Biology and Microbiology, California State University Los Angeles, 5151 State University Drive, Los Angeles, California 90032 (USA)US
  2. 2.Department of Medicine, UCLA School of Medicine, 10833 LeConte Ave, Los Angeles, California 90095 (USA), Fax +1 323 343 6451, e-mail: eporter@calstatela.eduUS
  3. 3.The Cleveland Clinic Foundation, Lerner Research Institute, Department of Immunology, 9500 Euclid Ave, Cleveland, Ohio 44195 (USA)US

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