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Cellular and Molecular Life Sciences CMLS

, Volume 58, Issue 7, pp 857–867 | Cite as

Human Genome and Diseases: A new series of reviews in CMLS¶Werner Syndrome: genetic and molecular basis of a premature aging disorder

  • M. Lebel

Abstract.

Werner syndrome (WS) is a rare autosomal recessive disorder characterized by genomic instability and by the premature onset of a number of age-related diseases, including cancers. The gene responsible for WS encodes a protein that has an exonuclease domain and a domain similar to DNA helicases of the RecQ-like subfamily. Accumulating evidence indicates that the WS gene product is involved in resolving aberrant DNA structures that may arise during the process of DNA replication and transcription. Such processes generate regions of single-stranded DNA that may inadvertently provide a substrate for the initiation of recombination. Various mechanisms have evolved to ensure that recombination does not occur promiscuously during these events, and results are consistent with a model in which the WS protein is part of one such mechanism.

Key words. Werner Syndrome; premature aging; genomic instability; helicases; topoisomerases; DNA replication; transcription; recombination. 

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Copyright information

© Birkhäuser Verlag, 2001

Authors and Affiliations

  • M. Lebel
    • 1
  1. 1.Centre de Recherche en Cancérologie de l'Université Laval, Pavillon Hôtel-Dieu-de-Québec, CHUQ, 9 rue McMahon, Québec (Québec G1R 2J6, Canada), Fax: +1 418 691 5439, e-mail: michel.lebel@crhdq.ulaval.caCA

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