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Inflammation Research

, Volume 50, Issue 5, pp 249–253 | Cite as

Eicosanoid production by human monocytes: does COX-2 contribute to a self-limiting inflammatory response?

  • M. J. James
  • P. S. Penglis
  • G. E. Caughey
  • M. Demasi
  • L. G. Cleland

Abstract:

The eicosanoids, prostaglandin E2 (PGE2) and thromboxane A2 (TXA2), are involved in inflammatory events. TXA2 has potentially pro-inflammatory actions and PGE2 has actions which can be considered both pro- and anti-inflammatory. Therefore, it is potentially significant that production of TXA2 and PGE2 by stimulated monocytes have very different time courses. TXA2 synthesis is immediate and dependent on cyclooxygenase Type 1 (COX-1) activity whereas PGE2 synthesis is delayed and dependent on COX-2 activity. These apparent COX-isotype dependencies of TXA2 and PGE2 synthesis can be explained by differences in the affinities of TXA synthase and PGE synthase for the common substrate, PGH2. The findings have implications for the use of NSAIDs and selective COX-2 inhibitors whose actions can increase the monocyte TXA2/PGE2 ratio.

Key words: COX-2 - Prostaglandin E2 - Thromboxane A2 - Monocyte 

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Copyright information

© Birkhäuser Verlag, 2001

Authors and Affiliations

  • M. J. James
    • 1
  • P. S. Penglis
    • 1
  • G. E. Caughey
    • 1
  • M. Demasi
    • 1
  • L. G. Cleland
    • 1
  1. 1.Rheumatology Unit, Royal Adelaide Hospital, North Terrace, Adelaide, SA, Australia 5000, Fax: 08 8222 5895, michael.james@adelaide.edu.au AU

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