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Inflammation Research

, Volume 47, Supplement 2, pp 112–116 | Cite as

COX-2 and colon cancer

  • M. M. Taketo

Abstract.

The role of cyclooxygenase-2 (COX-2) in colorectal tumorigenesis in mice was studied by Oshima et al. to determine the effects of COX-2 gene knockouts and a new COX-2 inhibitor. In the study, heterozygous Apc Δ716 knockout mice, a mouse model of human familial adenomatous polyposis (FAP), were either crossed to COX-2 gene knockout mice, or fed chow containing the COX-2-selective inhibitor. Apc Δ716 litter mates were used as positive controls, which developed 652 ± 198 (SD) polyps at 10 weeks. Introduction of a COX-2 gene mutation, or feeding with the COX-2-selective inhibitor to the Apc Δ716 knockout mice, reduced the number and size of intestinal polyps dramatically. The results provide direct genetic evidence that COX-2 plays a key role in tumorigenesis, and indicate that COX-2-selective inhibitors can be a new class of therapeutic agents for colorectal polyposis and cancer.

Key words: COX-2 — Colon cancer — Tumorigenesis — COX-2 inhibitors —ApcΔ716 

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Copyright information

© Birkhäuser Verlag, Basel, 1998

Authors and Affiliations

  • M. M. Taketo
    • 1
  1. 1.Laboratory of Biomedical Genetics, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunyo-ku, Tokyo 113, Japan, Fax +81 3 5802 8832, e-mail: taketo@mol.f.u-tokyo.ac.jpJP

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