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Inflammation Research

, Volume 46, Issue 11, pp 447–451 | Cite as

Glucocorticoid modulation of human monocyte/macrophage function: Control of TNF-α secretion

  • D. A. Joyce
  • J. H. Steer
  • L. J. Abraham

Abstract.

Glucocorticoids suppress many functions in activated monocyte/macrophages, including the release of TNF-α. This is likely to contribute to the efficacy of glucocorticoids in some inflammatory diseases, such as rheumatoid arthritis, where TNF-α contributes to pathogenesis. Glucocorticoids suppress the activity of reporters which include TNF-α promoter regions and modify the activity of NF-κB family transcription factors in activated human monocytic cell lines, suggesting effects of glucocorticoids on TNF-α gene transcription. In addition, glucocorticoids have been reported to antagonise the enhanced translational efficiency of TNF-α mRNA which occurs at least after stimulation of murine monocytic cells. It is likely, therefore, that glucocorticoids act at several points in stimulated monocyte/macrophages to reduce TNF-α secretion. Understanding glucocorticoid control of TNF-α secretion may explain some of the variability in response to GC in inflammatory diseases and may reveal means of inducing glucocorticoid-like anti-inflammatory effects in monocyte/macrophages without exposing other tissues to the adverse effects of glucocorticoids.

Key words: Glucocorticoids — TNF-α— Macrophage — Transcription factors — Promoter 

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Copyright information

© Birkhäuser Verlag, Basel, 1997

Authors and Affiliations

  • D. A. Joyce
    • 1
  • J. H. Steer
    • 1
  • L. J. Abraham
    • 2
  1. 1.Department of Pharmacology, University of Western Australia, Nedlands 6907, Western Australia, Fax +618 9346 3469, e-mail: djoyce@receptor.pharm.uwa.edu.auAU
  2. 2.Department of Biochemistry, University of Western Australia, Nedlands 6907, Western AustraliaAU

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