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Inflammation Research

, Volume 46, Issue 10, pp 382–391 | Cite as

Tissue injury in neutrophilic inflammation

  • F. Dallegri
  • L. Ottonello

Abstract.

The exudation of neutrophils is the hallmark of a form of inflammatory response occurring after tissue colonization by invading bacteria or as an expression of various non-infectious diseases. All these diseases are characterized by a high risk of developing irreversible tissue injury. Neutrophil-endothelium interactions, activation-induced functional and structural changes of responding neutrophils, regulatory systems of neutrophil function, and oxidative-proteolytic pathways responsible for histotoxicity are reviewed here. Finally, perspectives for rational approaches to handle the development of tissue injury during neutrophilic inflammation are considered.

Key words: Inflammation — Neutrophils — Oxidants — Proteinases — Anti-inflammatory drugs 

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Copyright information

© Birkhäuser Verlag, Basel, 1997

Authors and Affiliations

  • F. Dallegri
    • 1
  • L. Ottonello
    • 1
  1. 1.First Medical Clinic, Department of Internal Medicine, University of Genova, Medical School, Viale Benedetto XV 6, I-16132 Genova, Italy, Fax +39 10 352 324IT

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