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The advances in pyroptosis initiated by inflammasome in inflammatory and immune diseases

Abstract

Pyroptosis is a programmed and inflammatory cell death initiated by inflammasome. During pyroptosis, cytosolic pattern recognition receptors, apoptosis-associated speck-like protein and pro-Caspase-1 form activated inflammasome together. Caspase-1 activated by inflammasome results in generating an N-terminal cleavage product of gasdermin D (GSDMD), which is a major executor of pyroptosis. As a consequence of pyroptosis, a large number of pro-inflammatory cytokines are released including IL-1β and IL-18. Nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) and absent in melanoma 2 (AIM2)-like receptors (ALRs) belong to cytosolic pattern recognition receptors and assemble inflammasomes by detecting host cell damage signals. Pyroptosis pathways are divided into canonical and non-canonical pathways according to the identification of damage signals by cytoplasmic protein sensors. Pyroptosis not only plays an important role in infection, but also plays a vital role in inflammatory immune diseases. This article reviews the advances research of pyroptosis initiated by inflammasome in inflammatory and immune diseases.

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Acknowledgements

This study was funded by the National Natural Science Foundation of China (No. U1803129, 81803538 and 81673444).

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Correspondence to Lingling Zhang or Wei Wei.

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Liang, F., Zhang, F., Zhang, L. et al. The advances in pyroptosis initiated by inflammasome in inflammatory and immune diseases. Inflamm. Res. (2020). https://doi.org/10.1007/s00011-020-01315-3

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Keywords

  • Pyroptosis
  • Inflammasome
  • Inflammation
  • Immune
  • Diseases