The influence of ICAM1 rs5498 on diabetes mellitus risk: evidence from a meta-analysis
- 27 Downloads
Both type 1 diabetes (T1D) and type 2 diabetes (T2D) are classified as forms of diabetes mellitus (DM) and commonly considered inflammatory process. Intercellular adhesion molecule-1 (ICAM-1) is involved in the development and progression of diabetes mellitus. However, the genetic association between ICAM-1 rs5498, and T1D and T2D risk was inconclusive.
Materials and methods
A meta-analysis by searching the PubMed, Embase, Cochrane Library, and Chinese National Knowledge Infrastructure (CNKI) databases was performed out. The pooled odds ratio (OR) and 95% confidence interval (CI) were used to describe the strength of association of T1D and T2D risk.
A total of 14 studies encompassing 3233 cases and 2884 controls were included in the present meta-analysis. Significant associations were found between the allele and recessive models of ICAM1 rs5498 and DM in Asian population (allele: OR 1.13; 95% CI 1.03–1.23, p = 0.008; recessive: OR 1.25; 95% CI 1.06–1.48, p = 0.008), but not in Caucasian population (p > 0.05). In addition, the allele model of rs5498 was found to be significantly associated with the increased risk of T2D (OR 1.10; 95% CI 1.01–1.21, p = 0.03), but not T1D (p > 0.05).
The ICAM1 rs5498 might be a susceptible factor for T2D, but not T1D. And the allele and recessive models of ICAM1 rs5498 might be a risk factor in Asian population.
KeywordsDiabetes mellitus (DM) Intercellular adhesion molecule-1 (ICAM-1) Genetic association Meta-analysis
This study was funded by the Youth Foundation of the Education Department of Hunan (17B035) and the construct program of the key discipline in Hunan province.
Compliance with ethical standards
Conflict of interest
The authors declare no conflict of interest.
- 3.Francés DE, Ingaramo PI, Ronco MT, Carnovale CE. Diabetes, an inflammatory process: oxidative stress and TNF-alpha involved in hepatic complication. J Biomed Sci Eng. 2013;06(6):645–53.Google Scholar
- 6.Staeva-Vieira T, Peakman M. Von Herrath M. Translational mini-review series on type 1 diabetes: immune-based therapeutic approaches for type 1 diabetes. Clin Exp Immunol. 2010;148(1):17–31.Google Scholar
- 8.Laaksonen DE, Lakka HM, Niskanen LK, Kaplan GA, Salonen JT, Lakka TA. Metabolic syndrome and development of diabetes mellitus: application and validation of recently suggested definitions of the metabolic syndrome in a prospective cohort study. Am J Epidemiol. 2002;156(11):1070–77.PubMedGoogle Scholar
- 9.De Ferranti SD, Osganian SK. Epidemiology of paediatric metabolic syndrome and type 2 diabetes mellitus. Diabetes Vasc Dis Res. 2007;4(4):285–96.Google Scholar
- 11.Jae-Bung K, Mi-Hwa J, Je-Yeol C, Park JW, Suh JY, Lee JM. The influence of type 2 diabetes mellitus on the expression of inflammatory mediators and tissue inhibitor of metalloproteinases-2 in human chronic periodontitis. J Periodontal Implant Sci. 2011;41(3):109–16.Google Scholar
- 12.Kolseth IBM, Reine TM, Parker K, Sudworth A, Witczak BJ, Jenssen TG, et al. Increased levels of inflammatory mediators and proinflammatory monocytes in patients with type I diabetes mellitus and nephropathy. J Diabetes Complic. 2017;31(1):245–52.Google Scholar
- 14.Lontchi-Yimagou E, Sobngwi E, Matsha TE, Kengne AP. Diabetes mellitus and inflammation. Curr Diabetes Rep. 2013;13(3):435–44.Google Scholar
- 15.Wallet MA, Tisch R. Type 1 diabetes, inflammation and dendritic cells. Drug Discov Today Dis Mech. 2007;3(3):373–79.Google Scholar
- 17.Odegaard AO, Jacobs DR Jr, Sanchez OA, Goff DC Jr, Reiner AP, Gross MD. Oxidative stress, inflammation, endothelial dysfunction and incidence of type 2 diabetes. Cardiovasc Diabetol. 2016;15(51):1–12.Google Scholar
- 20.Navarro-GonzÃlez JF, Muros M, Mora-FernÃndez C, Herrera H, Meneses B, García J. Pentoxifylline for renoprotection in diabetic nephropathy: the PREDIAN study. Rationale and basal results. J Diabetes Complic. 2011;25(5):314–19.Google Scholar
- 22.Kumari V, Sarangapani S, Krishnamurthy P, Vaitheeswaran K, Sathyabaarathi R, Rajesh M, et al. ICAM-1K469E polymorphism is a genetic determinant for the clinical risk factors of T2D subjects with retinopathy in Indians: a population-based case–control study. BMJ Open. 2012;2(4):e001036.Google Scholar
- 27.Lv Z, Li Y, Wu Y, Qu Y. Association of ICAM-1 and HMGA1 gene variants with retinopathy in type 2 diabetes mellitus among Chinese individuals. Curr Eye Res. 2016;41(8):1–5.Google Scholar
- 28.Ma J, Möllsten A, Prázny M, Falhammar H, Brismar K, Dahlquist G, et al. Genetic influences of the intercellular adhesion molecule 1 (ICAM-1) gene polymorphisms in development of type 1 diabetes and diabetic nephropathy. Diabetes Med. 2006;23(10):1093–99.Google Scholar
- 29.Gu HF, Ma J, Gu KT, Brismar K. Association of intercellular adhesion molecule 1 (ICAM1) with diabetes and diabetic nephropathy. Front Endocrinol (Lausanne). 2013;3:179.Google Scholar
- 31.Wei YS, Liu YG, Huang RYl. Intercellular adhesion molecule-1 gene K469E polymorphism an d genetic susceptibility of ischemic stroke in Chinese Zhuang populations. Chin J Med Genet. 2005;22(3):305–8.Google Scholar
- 32.Kamiuchi K, Hasegawa G, Obayashi H, Kitamura A, Ishii M, Yano M, et al. Intercellular adhesion molecule-1 (ICAM-1) polymorphism is associated with diabetic retinopathy in Type 2 diabetes mellitus. Diabetes Med. 2010;19(5):371–76.Google Scholar
- 34.Ren Z, Ji N, Jia K, Wang L, Gu HF, Ma J. Association of the intercellular adhesion molecule-1 gene polymorphisms with type 2 diabetes and diabetic peripheral neuropathy in a Chinese Han population. Genes Genomics. 2015;37(1):69–75.Google Scholar
- 35.Seman Abu N, Anderstam B, Wan MW, Östenson CG, Brismar K, Gu HF. Genetic, epigenetic and protein analyses of intercellular adhesion molecule 1 in Malaysian subjects with type 2 diabetes and diabetic nephropathy. J Diabetes Complic. 2015;29(8):1234–9.Google Scholar
- 36.Popović D, Starčević JN, Letonja M, Makuc J, Vujkovac AC, Pleskovic RZ, et al. Polymorphism rs5498 of the ICAM-1 gene affects the progression of carotid atherosclerosis in patients with type 2 diabetes mellitus. Lipids Health Dis. 2016;15(1):1–7.Google Scholar
- 37.Zhou Y, Ping FU. Study on the gene polymorphism of intercellular adhesion molecule-1 in type 2 diabetes mellitus patients with retinopathy. J Chin Pract Diagn Ther. 2010;24:29–31.Google Scholar
- 38.Nejentsev S, Laine AP, Simell O, Ilonen J. Intercellular adhesion molecule-1 (ICAM-1) K469E polymorphism: no association with type 1 diabetes among Finns. Tissue Antigens. 2010;55(6):568–70.Google Scholar
- 41.Wells GA, Shea BJ, O’Connell D. The Newcastle–Ottawa Scale (NOS) for assessing the quality of non-randomized studies in meta-analysis. Appl Eng Agric. 2014;18:727–34.Google Scholar
- 43.Zou J, Wu D, Liu Y, Tan S. Association of luteinizing hormone/choriogonadotropin receptor gene polymorphisms with polycystic ovary syndrome risk: a meta-analysis. Gynecol Endocrinol. 2018;5:1–5.Google Scholar
- 46.Driver JP, Chen YG, Mathews CE. Comparative genetics: synergizing human and NOD mouse studies for identifying genetic causation of type 1 diabetes. Rev Diabetes Stud. 2012;9(4):169–87.Google Scholar
- 47.Amano K, Taki T, Hasegawa Y. Prevention of autoimmune IDDM in NOD mice by anti-LFA-1 and anti-ICAM-1 monoclonal-antibodies. Diabetologia. 1993;36:A10–0.Google Scholar
- 51.Brorsson C, Hansen NT, Lage K, Bergholdt R, Brunak S, Pociot F, et al. Identification of T1D susceptibility genes within the MHC region by combining protein interaction networks and SNP genotyping data. Diabetes Obes Metab. 2010;11(s1):60–6.Google Scholar
- 53.Vaag A, Brøns C, Gillberg L, Hansen NS, Hjort L, Arora GP, et al. Genetic, non-genetic and epigenetic risk determinants in developmental programming of type 2 diabetes. Acta Obstet Gynecol Scand. 2015;93(11):1099–108.Google Scholar
- 57.Basile KJ, Guy VC, Schwartz S, Grant SFA. Overlap of genetic susceptibility to type 1 diabetes, type 2 diabetes, and latent autoimmune diabetes in adults. Curr Diabetes Rep. 2014;14(11):1–7.Google Scholar
- 58.Leif G, Flemming P. Genetics of diabetes—are we missing the genes or the disease? Mol Cell Endocrinol. 2014;382(1):726–39.Google Scholar
- 59.Dooley J, Tian L, Schonefeldt S, Delghingaro-Augusto V, Garcia-Perez JE, Pasciuto E, et al. Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes. Nat Genet, 2016; 1–12.Google Scholar