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Nature is the best source of anti-inflammatory drugs: indexing natural products for their anti-inflammatory bioactivity

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Abstract

Objectives

The aim was to index natural products for less expensive preventive or curative anti-inflammatory therapeutic drugs.

Materials

A set of 441 anti-inflammatory drugs representing the active domain and 2892 natural products representing the inactive domain was used to construct a predictive model for bioactivity-indexing purposes.

Method

The model for indexing the natural products for potential anti-inflammatory activity was constructed using the iterative stochastic elimination algorithm (ISE). ISE is capable of differentiating between active and inactive anti-inflammatory molecules.

Results

By applying the prediction model to a mix set of (active/inactive) substances, we managed to capture 38% of the anti-inflammatory drugs in the top 1% of the screened set of chemicals, yielding enrichment factor of 38. Ten natural products that scored highly as potential anti-inflammatory drug candidates are disclosed. Searching the PubMed revealed that only three molecules (Moupinamide, Capsaicin, and Hypaphorine) out of the ten were tested and reported as anti-inflammatory. The other seven phytochemicals await evaluation for their anti-inflammatory activity in wet lab.

Conclusion

The proposed anti-inflammatory model can be utilized for the virtual screening of large chemical databases and for indexing natural products for potential anti-inflammatory activity.

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Acknowledgements

This work was partially supported by the Al-Qasemi Research Foundation (Grant no. 954000) and the Ministry of Science, Space and Technology, Israel. We declare that the funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Author information

Author notes

  1. Miran Aswad, Mahmoud Rayan, Saleh Abu-Lafi, Mizied Falah contributed equally to this paper.

Authors and Affiliations

  1. Eliachar Research Laboratory, Western Galilee Hospital, 22100, Nahariya, Israel

    Miran Aswad & Mizied Falah

  2. Institute of Applied Research-Galilee Society, 20200, Shefa-Amr, Israel

    Mahmoud Rayan, Ziyad Abdallah & Anwar Rayan

  3. Faculty of Pharmacy, Al-Quds University, P. Box 20002, Abu-Deis, Palestine

    Saleh Abu-Lafi & Jamal Raiyn

  4. Drug Discovery Informatics Lab, QRC-Qasemi Research Center, Al-Qasemi Academic College, 3010, Baka EL-Garbiah, Israel

    Anwar Rayan

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  1. Miran Aswad
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  2. Mahmoud Rayan
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  4. Mizied Falah
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Correspondence to Anwar Rayan.

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Responsible Editor: John Di Battista.

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Aswad, M., Rayan, M., Abu-Lafi, S. et al. Nature is the best source of anti-inflammatory drugs: indexing natural products for their anti-inflammatory bioactivity. Inflamm. Res. 67, 67–75 (2018). https://doi.org/10.1007/s00011-017-1096-5

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  • DOI: https://doi.org/10.1007/s00011-017-1096-5

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