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Inflammation Research

, Volume 66, Issue 3, pp 249–258 | Cite as

Genetic polymorphisms of IL-18 rs1946518 and IL-1β rs16944 are associated with prognosis and survival of acute myeloid leukemia

  • Hong Wang
  • Mingqiang Hua
  • Shukang Wang
  • Jie Yu
  • Chen Chen
  • Xueyun Zhao
  • Chen Zhang
  • Chaoqin Zhong
  • Ruiqing Wang
  • Na He
  • Ming Hou
  • Daoxin MaEmail author
Original Research Paper

Abstract

Background

Though the pathogenesis of AML is still unknown, accumulating evidence revealed that immune response plays a vital part in it. NLRP3 inflammasome as a component of immune system has been found related to several cancers. The single nucleotide polymorphisms (SNPs) of NLRP3 inflammasome genes may be related to pathogenesis and prognosis of AML.

Methods and results

We determined polymorphisms of NLRP3 (rs35829419), CARD8 (rs2043211), IL-1β (rs16944), IL-18 (rs1946518) and NF-κB −94 ins/del ATTG in de novo AML patients to find out whether they play roles in the susceptibility and severity of AML. In our study, 383 AML cases and 300 randomly selected healthy individuals were examined for the polymorphisms and expression of NLRP3 genes. IL-1β (rs16944) polymorphism in different risk AML subgroups was found statistically different, with more GA genotype in favorable-risk cytogenetics group. We also demonstrated that the bone marrow blasts of patients carrying IL-18 (rs1946518) GG or GT genotype were higher than patients of TT genotype. IL-18 plasma level of patients with IL-18 (rs1946518) GT or TT genotype was higher than GG genotype. Moreover, the GT genotype of IL-18 (rs1946518) led to statistically poorer AML-specific survival.

Conclusion

IL-1β (rs16944) and IL-18 (rs1946518) may be served as potential predictors for AML.

Keywords

Acute myeloid leukemia Polymorphism Inflammasome, NLRP3 Susceptibility 

Notes

Acknowledgements

This work was supported by grants from National Natural Science Foundation of China (No. 81470319, No. 81170515).

Compliance with ethical standards

Conflict of interest

We declare that there is no conflict of interest.

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Copyright information

© Springer International Publishing 2016

Authors and Affiliations

  • Hong Wang
    • 1
    • 2
  • Mingqiang Hua
    • 1
  • Shukang Wang
    • 3
  • Jie Yu
    • 1
  • Chen Chen
    • 1
  • Xueyun Zhao
    • 1
  • Chen Zhang
    • 1
  • Chaoqin Zhong
    • 1
  • Ruiqing Wang
    • 1
  • Na He
    • 1
  • Ming Hou
    • 1
  • Daoxin Ma
    • 1
    Email author
  1. 1.Department of Hematology, Qilu HospitalShandong UniversityJinanPeople’s Republic of China
  2. 2.Department of HematologyZibo Central HospitalZiboPeople’s Republic of China
  3. 3.Department of Epidemiology and Biostatistics, School of Public HealthShandong UniversityJinanPeople’s Republic of China

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