Sigma-1 receptor and inflammatory pain
The sigma-1 receptor (Sig-1R) is a unique ligand-regulated molecular chaperone that interacts with several protein targets such as G protein-coupled receptors and ion channels to modulate their activity. Sig-1R is located in areas of the central and peripheral nervous system that are key to pain control. Previous preclinical studies have suggested a potential therapeutic use of Sig-1R antagonists for the management of neuropathic pain.
Recent studies using pharmacological and genetic tools have explored the role of Sig-1R in inflammatory pain conditions. Mice lacking the Sig-1R have shown different patterns of phenotypic responses to inflammatory injury. Systemic or peripheral administration of several Sig-1R antagonists, including the selective Sig-1R antagonist S1RA, inhibited both mechanical and thermal hypersensitivity in several preclinical models of inflammatory pain. These recent studies are summarized in the present commentary.
Central and peripheral pharmacological blockade of Sig-1R could be an effective option to treat inflammatory pain.
KeywordsSigma-1 receptor Inflammatory pain Analgesic Arthritis Carrageenan Complete Freund’s adjuvant
Enrique J Cobos was partially supported by Grant SAF2013-47481-P from the Spanish Government (Madrid, Spain), FEDER funds, Grant CTS109 from the Junta de Andalucía (Seville, Spain), and the Research Program of the University of Granada.
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