Inflammation Research

, Volume 63, Issue 4, pp 255–265 | Cite as

Linking GATA-3 and interleukin-13: implications in asthma

  • Sheikh Rayees
  • Fayaz Malik
  • Syed Imran Bukhari
  • Gurdarshan Singh
Review

Abstract

Introduction

Asthma is one of the serious global health problems and cause of huge mortality and morbidity. It is characterized by persistent airway inflammation, airway hyperresponsiveness, increased IgE levels and mucus hypersecretion. Asthma is mediated by dominant Th2 immune response, causing enhanced expression of Th2 cytokines. These cytokines are responsible for the various pathological changes associated with allergic asthma.

Materials and methods

The role of Th2 cells in the pathogenesis of the asthma is primarily mediated through the cytokine IL-13, also produced by type 2 innate lymphoid cells, that comes under the transcriptional regulation of GATA3. In this review we will try to explore the link between IL-13 and GATA3 in the progression and regulation of asthma and its possible role as a therapeutic target.

Conclusion

Inhibition of GATA3 activity or blockade of GATA3 expression may attenuate the interleukin-13 mediated asthma phenotypes. So, GATA3 might be a potential therapeutic target for the treatment of allergic asthma.

Keywords

Asthma Eosinophils Lymphocytes Airway hypersensitivity IL-13 GATA3 

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Copyright information

© Springer Basel 2013

Authors and Affiliations

  • Sheikh Rayees
    • 1
  • Fayaz Malik
    • 2
  • Syed Imran Bukhari
    • 3
  • Gurdarshan Singh
    • 1
    • 4
  1. 1.Pharmacology DivisionIndian Institute of Integrative Medicine (CSIR)JammuIndia
  2. 2.Experimental Breast Cancer Research LaboratoryUniversity of MichiganAnn ArborUSA
  3. 3.Department of BiotechnologyUniversity of JammuJammuIndia
  4. 4.PK-PD Toxicology DivisionIndian Institute of Integrative Medicine (CSIR)JammuIndia

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