Inflammation Research

, Volume 61, Issue 5, pp 437–444 | Cite as

Barrier protective activities of curcumin and its derivative

  • Dong-Chan Kim
  • Sae-Kwang Ku
  • Wonhwa Lee
  • Jong-Sup Bae
Original Research Paper

Abstract

Aim and objective

Curcumin, a poly-phenolic compound, possesses diverse pharmacologic activities. However, the barrier protective functions of curcumin or its derivative have not yet been studied. The objective of this study was to investigate the barrier protective activities of curcumin and its derivative (bisdemethoxycurcumin, BDMC) on lipopolysaccharide (LPS) barrier disruption in human umbilical vein endothelial cells (HUVECs) were investigated.

Methods

The barrier protective effects of curcumin and BDMC such as permeability, expression of cell adhesion molecules, monocytes adhesion and migration toward HUVECs were tested.

Results

Curcumin and BDMC inhibited LPS-induced barrier permeability, monocyte adhesion and migration; inhibitory effects were significantly correlated with inhibitory functions of curcumin and BDMC on LPS-induced cell adhesion molecules (vascular cell adhesion molecules, intracellular cell adhesion molecule, E-selectin). Furthermore, LPS-induced nuclear factor-κB (NF-κB) activation and tumor necrosis factor-α (TNF-α) release from HUVECs were inhibited by curcumin and BDMC. Surprisingly, the barrier protective activities of BDMC were better than those of curcumin, indicating that the methoxy group in curcumin negatively regulated barrier protection function of curcumin.

Conclusion

Given these results, curcumin or its derivative, BDMC, showed barrier protective activities and they could be a therapeutic candidates for various systemic inflammatory diseases.

Keywords

Curcumin Bisdemethoxycurcumin Barrier integrity LPS 

Abbreviations

LPS

Lipopolysaccharide

CAM

Cell adhesion molecule

VCAM

Vascular cell adhesion molecules

ICAM

Intracellular cell adhesion molecule

NF-κB

Nuclear factor-κB

TNF

Tumor necrosis factor

BDMC

Bisdemethoxycurcumin

TEM

Transendothelial migration

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Copyright information

© Springer Basel AG 2012

Authors and Affiliations

  • Dong-Chan Kim
    • 1
  • Sae-Kwang Ku
    • 2
  • Wonhwa Lee
    • 3
    • 4
  • Jong-Sup Bae
    • 4
  1. 1.Laboratory of Microvascular Circulation ResearchNEUORNEX Inc.DaeguRepublic of Korea
  2. 2.Department of Anatomy and Histology, College of Oriental MedicineDaegu Haany UniversityGyeongsanRepublic of Korea
  3. 3.Department of Biochemistry and Cell Biology, School of MedicineKyungpook National UniversityDaeguRepublic of Korea
  4. 4.College of Pharmacy, Research Institute of Pharmaceutical SciencesKyungpook National UniversityDaeguRepublic of Korea

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