Inflammation Research

, Volume 59, Supplement 2, pp 253–255 | Cite as

Cryotherapy decreases histamine levels in the blood of patients with rheumatoid arthritis

  • E. Wojtecka-Lukasik
  • K. Ksiezopolska-Orlowska
  • E. Gaszewska
  • O. Krasowicz-Towalska
  • P. Rzodkiewicz
  • D. Maslinska
  • D. Szukiewicz
  • S. Maslinski
Short Communication

Abstract

Introduction

Conventional physiotherapy (electrotherapy, magnetic fields), kinesitherapy, and whole-body cryotherapy (plus kinesitherapy) are used to relieve pain and inflammation or to improve function in rheumatic diseases. The aim of this study was to investigate the effects of different physiotherapies and cryotherapy on biochemical blood parameters of patients with rheumatoid arthritis (RA) and osteoarthritis (OA).

Materials and methods

Twenty patients with RA and 17 patients with OA received whole-body cryotherapy at −140 to −160°C for 2 to 3 min, once daily for 4 weeks. The second group of patients (24 with RA and 28 with OA) received conventional physiotherapy for 4 weeks. We measured the parameters of neutrophil activation (respiratory burst, calprotectin) and markers of cartilage metabolism [N-acetyl-beta-D-hexosaminidase (NAHase), ectonucleotide pyrophosphohydrolase (NTPPHase)] twice: before and 3 months after cryotherapy or physiotherapy.

Results

We showed, for the first time, that cryotherapy significantly reduced (P < 0.001) histamine levels in the blood of patients with RA. The effect was long-lasting (for at least 3 months). The levels of blood histamine in patients with OA were not changed significantly. Cryotherapy also downregulated the respiratory burst of PMNs and NAHase activity and upregulated calprotectin levels and the activity of NTPPHase. However, these changes were not statistically significant. In contrast, there were no significant changes in histamine levels or the other biochemical parameters measured in groups of patients treated only with physiotherapy and kinesitherapy.

Conclusion

It may be concluded that the beneficial clinical effects of cryotherapy in RA patients are in part due to the action on the production, release, or degradation of histamine.

Keywords

Rehabilitation Cryotherapy Histamine Respiratory burst Cartilage metabolism 

References

  1. 1.
    Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 1988;31:315–24.CrossRefPubMedGoogle Scholar
  2. 2.
    Altman R, Asch E, Bloch D, Bole G, Borenstein D, Brandt K, et al. Development of criteria for the classification and reporting of osteoarthritis of the knee: diagnostic and therapeutic criteria committee of the American Rheumatism Association. Arthritis Rheum. 1986;29:1039–49.CrossRefPubMedGoogle Scholar
  3. 3.
    Gabriels S. The epidemiology of rheumatoid arthritis. Rheum Dis Clin North Am. 2001;27:269–81.CrossRefGoogle Scholar
  4. 4.
    Shore P, Burkhalter A, Cohn W. A method for the fluorometric assay of histamine in tissues. J Pharmacol Exp Ther. 1959;127:182–6.PubMedGoogle Scholar
  5. 5.
    Wojtecka-Lukasik E, Maslinski W, Maslinski S. Stimulation of the human neutrophil respiratory burst by Il-15. J Physiol Pharmacol. 1997;48(Suppl 2):66–71.Google Scholar

Copyright information

© Birkhäuser Verlag, Basel/Switzerland 2009

Authors and Affiliations

  • E. Wojtecka-Lukasik
    • 1
  • K. Ksiezopolska-Orlowska
    • 2
  • E. Gaszewska
    • 2
  • O. Krasowicz-Towalska
    • 2
  • P. Rzodkiewicz
    • 1
  • D. Maslinska
    • 3
  • D. Szukiewicz
    • 4
  • S. Maslinski
    • 1
    • 4
  1. 1.Department of BiochemistryInstitute of RheumatologyWarsawPoland
  2. 2.Department of RehabilitationInstitute of RheumatologyWarsawPoland
  3. 3.Department of Developmental NeuropathologyMedical Research CentreWarsawPoland
  4. 4.Department of PathophysiologyMedical University of WarsawWarsawPoland

Personalised recommendations