Shedding light on DARC: the role of the Duffy antigen/receptor for chemokines in inflammation, infection and malignancy
- 308 Downloads
Duffy antigen (Fy) was first identified in 1950 as a cause of transfusion reactions , and 25 years later recognized as receptor allowing the entry of Plasmodium vivax into erythrocytes . It was not until the mid 1990s that a physiological role for this antigen was proposed, when Duffy was found to be a chemokine receptor  and was subsequently renamed Duffy antigen receptor for chemokines (DARC). Since then roles for DARC in inflammation, infection and malignancy have begun to emerge.
Most individuals from Sub-Saharan Africa, or of African descent, have a mutation that prevent DARC expression on erythrocytes, but not other sites of DARC expression, such as endothelial cells. Interest in the clinical and scientific implications of DARC has risen as it has become a potential explanation for some of the differences in prognosis and presentation seen in those with African genealogy in diseases of inflammation and malignancy.
This paper reviews the evidence for DARC...
KeywordsGiant Cell Arteritis Neutrophil Migration Delay Graft Function Vivax Infection Crescentic Glomerulonephritis
- 8.Middleton J, Americh L, Gayon R, Julien D, Mansat M, Mansat P, et al. A comparative study of endothelial cell markers expressed in chronically inflamed human tissues: MECA-79, Duffy antigen receptor for chemokines, von Willebrand factor, CD31, CD34, CD105 and CD146. J Pathol. 2005;206:260–8.PubMedCrossRefGoogle Scholar
- 22.Velzing-Aarts FV, van der Dijs FP, Muskiet FA, Duits AJ. The association of pre-eclampsia with the Duffy negative phenotype in women of West African descent. Br J Obstet Gynecol. 2002;109:453–5.Google Scholar