Inflammation Research

, Volume 57, Issue 11, pp 512–518

Hydrogen sulphide is pro-inflammatory in haemorrhagic shock

Article

DOI: 10.1007/s00011-008-7231-6

Cite this article as:
Mok, YY.P. & Moore, P.K. Inflamm. res. (2008) 57: 512. doi:10.1007/s00011-008-7231-6

Abstract:

Objective:

H2S is pro-inflammatory in inflammatory models, thus we investigated whether H2S plays a role in haemorrhagic shock (HS)-associated inflammation.

Methods:

Male, Sprague-Dawley rats were given an inhibitor of H2S biosynthesis, DL-propargylglycine (PAG, 50 mg/kg, i. v.) or saline (1 ml/kg) 30 min before blood withdrawal and subjected to HS (mean arterial pressure (MAP) of 40 mM Hg for 90 min) followed by reinfusion of shed blood. Animals were killed at 5, 90, 270 and 630 min after reinfusion.

Results:

Pre-treatment of animals with PAG 1) increased the HR recovery rate (n = 6 – 12, P < 0.05); 2) attenuated the increase in plasma levels of TNF-α and IL-6 and reduced lung iNOS expression levels (n =5 P, < 0.05); and 3) attenuated the increase in plasma levels of ALT and reduced HS-induced increase in liver and lung myeloperoxidase (MPO) activity (n = 5, P < 0.05).

Conclusions:

H2S is pro-inflammatory in HS and inhibition of H2S biosynthesis may reduce some HS-induced inflammatory responses and organ injury.

Keywords:

Inflammation Cytokines Rat Cystathionine-γ-lyase DL-propargylglycine 

Copyright information

© Birkhaueser 2008

Authors and Affiliations

  1. 1.Institute of Medical BiologySingaporeSingapore
  2. 2.Cardiovascular Biology Research Group, Centre For Life SciencesSingaporeSingapore

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