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Inflammation Research

, Volume 57, Issue 6, pp 279–286 | Cite as

Effects of magnesium supplementation on the glutathione redox system in atopic asthmatic children

  • O. BedeEmail author
  • D. Nagy
  • A. Surányi
  • I. Horváth
  • M. Szlávik
  • K. Gyurkovits
Article

Abstract.

Objective:

Our aim was to investigate the effects of 12-week oral magnesium (Mg) supplementation on the RBC redox system in stable, persistent, moderately asthmatic children (N = 40, 24 boys, 16 girls) aged 4–16 years in a randomized, double-blind, placebo-controlled study.

Design:

Oxidized (GSSG) and reduced (GSH) glutathione, oxyhaemoglobin, methaemoglobin (metHb), hemichrome and bilirubin levels before and after treatment were determined, and GSH stability tests were performed.

Result:

The GSH concentration was significantly higher in the Mg-treated than in the placebo-treated patients after the treatment period. There was a positive correlation between the decreased plasma metHb and hemichrome levels and the decreased plasma haemoglobin concentrations in the Mg-treated patients at the end of the study.

Conclusion:

Mg in the given doses exerts antioxidant activity and influences the glutathione redox system.

Keywords:

Bronchial asthma Oxidative stress Glutathione redox system Magnesium supplementation 

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Copyright information

© Birkhaueser 2008

Authors and Affiliations

  • O. Bede
    • 1
    Email author
  • D. Nagy
    • 1
  • A. Surányi
    • 2
  • I. Horváth
    • 3
  • M. Szlávik
    • 4
  • K. Gyurkovits
    • 4
  1. 1.Paediatric Department, Albert Szent-Györgyi Medical and Pharmaceutical CentreUniversity of SzegedSzegedHungary
  2. 2.Central Clinical Chemical Laboratory, Albert Szent-Györgyi Medical and Pharmaceutical CentreUniversity of SzegedSzegedHungary
  3. 3.Department of PathophysiologyNational Korányi Institute for TB and PulmonologyBudapestHungary
  4. 4.Hospital for Chest Diseases of the Hungarian Reformed ChurchMosdósHungary

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