Inflammation Research

, Volume 56, Issue 6, pp 221–227 | Cite as

Is cystic fibrosis a TH17 disease?

  • P. J. Dubin
  • F. McAllister
  • J. K. KollsEmail author


Cystic Fibrosis (CF) is the most common lethal genetic disease in the Caucasian population and typically results in the development of bronchial inflammation, bronchiectasis, the progressive loss of lung function and ultimately death. Recently it has been shown that products of the Th17 subset of T-cells, specifically, IL-17A and IL-17F are elevated in the sputum of CF patients. This review will go over experimental evidence supporting a role for the IL- 23/IL-17 axis in CF lung inflammation.


Cystic Fibrosis Cystic Fibrosis Transmembrane Conductance Regulator Cystic Fibrosis Patient Bronchiectasis Neutrophil Recruitment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Birkhäuser Verlag, Basel 2007

Authors and Affiliations

  1. 1.University of Pittsburgh, Children’s Hospital of PittsburghPittsburghUSA

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