Inflammation Research

, Volume 56, Issue 5, pp 210–215

Quercetin inhibits expression of inflammatory cytokines through attenuation of NF-κB and p38 MAPK in HMC-1 human mast cell line

  • Y.-D. Min
  • C.-H. Choi
  • H. Bark
  • H.-Y. Son
  • H.-H. Park
  • S. Lee
  • J.-W. Park
  • E.-K. Park
  • H.-I. Shin
  • S.-H. Kim
Article

Abstract.

Objective and design:

Mast cell-mediated allergic inflammation is involved in many diseases such as asthma, sinusitis, and rheumatoid arthritis. Mast cells induce production of pro-inflammatory cytokines with immune regulatory properties. We investigated the effect of quercetin on the expression of pro-inflammatory cytokines in human mast cell line, HMC-1.

Methods:

HMC-1 cells were stimulated with phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187 (PMACI).

Results:

Quercetin decreased the gene expression and production of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, and IL-8 in PMACI-stimulated HMC-1 cells. Quercetin attenuated PMACI-induced activation of NF-κB and p38 mitogen-activated protein kinase.

Conclusion:

Our study provides evidence that quercetin may suitable for the treatment of mast cell-derived allergic inflammatory diseases.

Keywords:

Quercetin Mast cell Allergic inflammation Pro-inflammatory cytokine 

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Copyright information

© Birkhäuser Verlag, Basel 2007

Authors and Affiliations

  • Y.-D. Min
    • 1
  • C.-H. Choi
    • 2
  • H. Bark
    • 2
  • H.-Y. Son
    • 3
  • H.-H. Park
    • 3
  • S. Lee
    • 3
  • J.-W. Park
    • 4
  • E.-K. Park
    • 5
  • H.-I. Shin
    • 5
  • S.-H. Kim
    • 3
  1. 1.Department of SurgeryChosun University Medical SchoolGwangjuRepublic of Korea
  2. 2.Department of PharmacologyChosun University Medical SchoolGwangjuRepublic of Korea
  3. 3.Department of Pharmacology, School of MedicineKyungpook National UniversityDaeguRepublic of Korea
  4. 4.Department of PeriodontologyKyungpook National UniversityDaeguRepublic of Korea
  5. 5.Department of Pathology and Regenerative Medicine, School of DentistryKyungpook National UniversityDaeguRepublic of Korea

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