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Inflammation Research

, Volume 56, Issue 2, pp 51–57 | Cite as

The relevance of sleep abnormalities to chronic inflammatory conditions

  • Z. Ranjbaran
  • L. Keefer
  • E. Stepanski
  • A. Farhadi
  • A. Keshavarzian
Review

Abstract.

Sleep is vital to health and quality of life while sleep abnormalities are associated with adverse health consequences. Nevertheless, sleep problems are not generally considered by clinicians in the management of chronic inflammatory conditions (CIC) such as asthma, RA, SLE and IBD. To determine whether this practice is justified, we reviewed the literature on sleep and chronic inflammatory diseases, including effects of sleep on immune system and inflammation.

We found that a change in the sleep-wake cycle is often one of the first responses to acute inflammation and infection and that the reciprocal effect of sleep on the immune system in acute states is often protective and restorative. For example, slow wave sleep can attenuate proinflammatory immune responses while sleep deprivation can aggravate those responses.

The role of sleep in CIC is not well explored. We found a substantial body of published evidence that sleep disturbances can worsen the course of CIC, aggravate disease symptoms such as pain and fatigue, and increase disease activity and lower quality of life. The mechanism underlying these effects probably involves dysregulation of the immune system. All this suggests that managing sleep disturbances should be considered as an important factor in the overall management of CIC.

Keywords:

Sleep Immune system Inflammation Asthma Rheumatoid arthritis Systemic Lupus Erythematosus Inflammatory bowel disease 

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Copyright information

© Birkhäuser Verlag, Basel 2007

Authors and Affiliations

  • Z. Ranjbaran
    • 1
  • L. Keefer
    • 1
  • E. Stepanski
    • 1
  • A. Farhadi
    • 1
  • A. Keshavarzian
    • 1
  1. 1.Section of Gastroenterology and NutritionRush University Medical CenterChicagoUSA

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