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Inflammation Research

, Volume 53, Issue 10, pp 509–516 | Cite as

Histamine H3-receptor isoforms

  • R. A. BakkerEmail author
Review

Abstract.

Increasing evidence supports a role for HA as a neurotransmitter and neuromodulator in various brain functions, including emotion, cognition, and feeding. The recent cloning of the histamine H3 receptor allowed for the subsequent cloning of a variety of H3 receptor isoforms from different species as well as the H4 receptor. As a result a wide variety of H3-receptor isoforms are now known that display differential brain expression patterns and signalling properties. These recent discoveries are discussed in view of the growing interest of the H3 receptor as a target for the development of potential therapeutics.

Key words.

Histamine H3 receptors Neurotransmitter Brain expression of H3-R CNS functions 

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Copyright information

© Birkhäuser Verlag, Basel 2004

Authors and Affiliations

  1. 1.Leiden/Amsterdam Center for Drug Research, Department of Medicinal ChemistryVrije Universiteit AmsterdamAmsterdamThe Netherlands

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