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Role of Monocytes in the Pathogenesis of Dengue

  • Jorge Andrés Castillo
  • Juan Sebastián Naranjo
  • Mauricio Rojas
  • Diana Castaño
  • Paula Andrea VelillaEmail author
Review

Abstract

Diseases caused by dengue virus (DENV) are a major public health problem worldwide, considered one of the infections with more prevalence in tropical and subtropical zones of the world. Despite the intense research in the pathogenesis of DENV, this feature is not well understood. One of the main target cells for DENV infection is monocytes; these phagocytes can play a dual role, since they are essential to control viremia, but they also participate in the induction of tissue damage during DENV infection. Monocytes produce different pro-inflammatory cytokines and chemokines in response to infection, and also mediate endothelial damage. In peripheral blood, monocytes can be divided into three different subpopulations, namely classical, intermediate and non-classical, which differ in frequency, cytokine production, among others. Studies in the last years suggest that non-classical monocytes have higher affinity for microvasculature endothelium compared to other type of monocytes, which implies that they could be more involved in the increase of endothelial permeability observed during DENV infection. This review provides a general view of the role of monocytes and their subpopulations in DENV pathogenesis and its effect in viral replication. Finally, the potential contribution of these phagocytes in the alterations of endothelial permeability is discussed.

Keywords

Dengue virus Monocytes Monocyte subpopulations Endothelial permeability Dengue virus pathogenesis 

Notes

Acknowledgements

This work was supported by COLCIENCIAS (111556933247) and by Universidad de Antioquia (Sostenibilidad). The authors wish to thank Anne-Lise Haenni for her constructive comments.

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Copyright information

© L. Hirszfeld Institute of Immunology and Experimental Therapy, Wroclaw, Poland 2018

Authors and Affiliations

  • Jorge Andrés Castillo
    • 1
  • Juan Sebastián Naranjo
    • 2
  • Mauricio Rojas
    • 2
    • 3
  • Diana Castaño
    • 2
  • Paula Andrea Velilla
    • 1
    Email author
  1. 1.Grupo de Inmunovirología. Departamento de Microbiología y Parasitología, Facultad de MedicinaUniversidad de Antioquia UdeAMedellínColombia
  2. 2.Grupo de Inmunología Celular e Inmunogenética (GICIG). Instituto de Investigaciones Médicas, Facultad de MedicinaUniversidad de Antioquia UdeAMedellínColombia
  3. 3.Unidad de Citometría, Facultad de Medicina, Sede de Investigación UniversitariaUniversidad de Antioquia UdeAMedellínColombia

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