Prostate Cancer Stem Cells: Viewing Signaling Cascades at a Finer Resolution
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It is becoming characteristically more understandable that within tumor cells, there lies a sub-population of tumor cells with “stem cell” like properties and remarkable ability of self-renewal. Many features of these self-renewing cells are comparable with normal stem cells and are termed as “cancer stem cells”. Accumulating experimentally verified data has started to scratch the surface of spatio-temporally dysregulated intracellular signaling cascades in the biology of prostate cancer stem cells. We partition this multicomponent review into how different signaling cascades operate in cancer stem cells and how bioactive ingredients isolated from natural sources may modulate signaling network.
KeywordsProstate cancer stem cells Apoptosis Molecular therapeutics Intracellular signaling
The study was supported in part by National Foundation of Natural Sci. of China (81302906, 81273550, 81573457 and 41306157), as well as Natural Sci. Foundation of Shandong province of China (ZR2014HQ031 and ZR2015HQ027). The authors would like to pay sincere thanks to Prof. F. H. Sarkar who helped in the structuring and conditioning of the review. He helped in English language editing of the manuscript.