Glioblastoma, a Brief Review of History, Molecular Genetics, Animal Models and Novel Therapeutic Strategies

  • Sameer Agnihotri
  • Kelly E. Burrell
  • Amparo Wolf
  • Sharzhad Jalali
  • Cynthia Hawkins
  • James T. Rutka
  • Gelareh Zadeh
Review

Abstract

Glioblastoma (GBM) is the most common and lethal primary brain tumor. Over the past few years tremendous genomic and proteomic characterization along with robust animal models of GBM have provided invaluable data that show that “GBM”, although histologically indistinguishable from one another, are comprised of molecularly heterogenous diseases. In addition, robust pre-clinical models and a better understanding of the core pathways disrupted in GBM are providing a renewed optimism for novel strategies targeting these devastating tumors. Here, we summarize a brief history of the disease, our current molecular knowledge, lessons from animal models and emerging concepts of angiogenesis, invasion, and metabolism in GBM that may lend themselves to therapeutic targeting.

Keywords

Glioblastoma Molecular genetics of glioma Mouse models Novel molecular targets 

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Copyright information

© L. Hirszfeld Institute of Immunology and Experimental Therapy, Wroclaw, Poland 2012

Authors and Affiliations

  • Sameer Agnihotri
    • 1
  • Kelly E. Burrell
    • 1
  • Amparo Wolf
    • 1
  • Sharzhad Jalali
    • 1
  • Cynthia Hawkins
    • 1
    • 2
  • James T. Rutka
    • 1
    • 3
  • Gelareh Zadeh
    • 1
    • 4
  1. 1.Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick ChildrenUniversity of TorontoTorontoCanada
  2. 2.Department of Neuropathology, Hospital for Sick ChildrenUniversity of TorontoTorontoCanada
  3. 3.Department of Neurosurgery, Hospital for Sick ChildrenUniversity of TorontoTorontoCanada
  4. 4.Department of Neurosurgery, Western HospitalUniversity of TorontoTorontoCanada

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