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The Role and Regulation of mTOR in T-Lymphocyte Function

  • Thomas F. O’Brien
  • Xiao-Ping ZhongEmail author
Review

Abstract

The conversion of naïve T cells into effector T cells is initiated by stimulation through the T-cell receptor (TCR). Upon activation, T cells undergo significant morphological and functional changes, putting new metabolic demands on the cell. Past research has identified the mammalian target of rapamycin (mTOR) as a critical regulator of cell metabolism, and the development of new genetic models has begun to reveal an important role for this pathway in the homeostasis and function of T lymphocytes. In this review, we focus on the most recent findings that demonstrate the ability of mTOR to regulate T-cell activation, CD8+ memory cell formation and function, and helper T lineage differentiation. Furthermore, we highlight the importance of tight control of mTOR signaling by tuberous sclerosis complex 1 for T-cell homeostasis, and the regulation of mTOR signaling by diacylglycerol kinases and the RasGRP1-Ras-Erk1/2 pathway in the context of TCR signaling.

Keywords

Mammalian target of rapamycin Tuberous sclerosis complex 1 Diacylglycerol kinase RasGPP1 PI3K/Akt T lymphocyte 

Notes

Acknowledgments

We thank Dr. Balachandra Gorentla for his helpful discussions regarding this work and Sruti Srivatsan for helpful discussions and editing the manuscript. This study is supported by funding from the National Institute of Health (R01AI076357, R01AI079088, and R21AI079873), the American Cancer Society (RSG-08-186-01-LIB), and the American Heart Association.

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Copyright information

© L. Hirszfeld Institute of Immunology and Experimental Therapy, Wroclaw, Poland 2012

Authors and Affiliations

  1. 1.Department of Pediatrics-Allergy and ImmunologyDuke University Medical CenterDurhamUSA
  2. 2.Department of ImmunologyDuke University Medical CenterDurhamUSA

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