Archivum Immunologiae et Therapiae Experimentalis

, Volume 59, Issue 6, pp 407–419 | Cite as

Complement in Cancer and Cancer Immunotherapy

Review

Abstract

Recently, there has been an increase of interest in the use of biological or immune-based therapies for patients with malignancies. This has been informed by the deeper understanding of the crosstalk between the host immune system and malignant tumours, as well as the potential advantages of immunotherapy—high specificity and less toxicity compared to standard approaches. The particular emphasis of this article is on the role of the complement system in tumour growth and antibody-based cancer immunotherapy. The functional consequences from overexpression of complement regulators by tumours and the development of strategies for overcoming this are discussed in detail. This review discusses these issues with a view to inspiring the development of new agents that could be useful for the treatment of cancer.

Keywords

Immunotherapy Cancer Complement Complement regulators Complement-dependent cytotoxicity (CDC) Antibody-dependent cell-mediated cytotoxicity (ADCC) 

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Copyright information

© L. Hirszfeld Institute of Immunology and Experimental Therapy, Wroclaw, Poland 2011

Authors and Affiliations

  1. 1.Department of Infection, Immunity and Biochemistry, School of MedicineCardiff UniversityCardiffUK
  2. 2.Institute of Life Science, College of MedicineSwansea UniversitySwanseaUK

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