Archivum Immunologiae et Therapiae Experimentalis

, Volume 59, Issue 6, pp 421–429

Islet Transplantation: Factors in Short-Term Islet Survival

  • Natasha A. Deters
  • Rebecca A. Stokes
  • Jenny E. Gunton
Review

Abstract

Islet transplantation has the potential to cure type 1 diabetes. In recent years, the proportion of patients achieving initial insulin independence has improved, but longer term outcomes remain poor compared to those for whole pancreas transplants. This review article will discuss factors affecting islet yield and viability leading up to transplantation and in the immediate post-transplant period.

Keywords

Islet transplantation Apoptosis Hypoxia Type 1 diabetes β cell 

Abbreviations

ADSC

Adipose derived stem cells

IBMIR

Instant blood-mediated inflammatory reaction

MSC

Mesenchymal stem cells

SC

Sertoli cells

T1D

Type 1 diabetes

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Copyright information

© L. Hirszfeld Institute of Immunology and Experimental Therapy, Wroclaw, Poland 2011

Authors and Affiliations

  • Natasha A. Deters
    • 1
  • Rebecca A. Stokes
    • 1
  • Jenny E. Gunton
    • 1
  1. 1.Diabetes and Transcription FactorsGarvan Institute of Medical ResearchDarlinghurstAustralia

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