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Modulation of apoptosis signaling for cancer therapy

  • Simone Fulda
  • Klaus-Michael Debatin
Review

Abstract.

Apoptosis, the cell’s intrinsic death program, plays a central role in regulating tissue homeostasis. Also, most cytotoxic therapies used for cancer treatment, such as chemotherapy, γ-irradiation, suicide genes, or immunotherapy, predominantly act by triggering apoptosis in target cells. Thus, understanding the molecular events that regulate apoptosis and how tumor cells evade apoptotic deletion have provided a paradigm to link cancer genetics and response to cancer therapy. Therefore, insights into the mechanisms regulating drug-induced apoptosis provide rational targets for novel therapeutic interventions.

Keywords.

apoptosis cancer therapy resistance 

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Copyright information

© Birkhäuser Verlag, Basel 2006

Authors and Affiliations

  1. 1.University Children’s HospitalUlmGermany

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