, Volume 26, Issue 6, pp 389–391 | Cite as

cDNA characterization of an Ly-6.2 gene expressed in BW5147 tumor cells

  • Roger G. E. Palfree
  • Kenneth P. LeClair
  • Alfred Bothwell
  • Ulrich Hämmerling
Gene-antigen register


Tumor Cell BW5147 Tumor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Dumont, F. J.: Treatment of resting T lymphocytes with interferon α/β augments their proliferative response to activation signals delivered through their surface Ly-6 antigen. Cell. Immunol. 101: 625–632, 1986Google Scholar
  2. Dumont, F. J., Coker, L. Z., Habbersett, R. C., and Treffinger, J. A.: Xenogeneic monoclonal antibody to an Ly-6 linked munine cell surface antigen: Differential activity with T cell subpopulations and bone marrow cells. J. Immunol. 134: 2357–2365, 1985Google Scholar
  3. Dumont, F. J., Palfree, R. G. E., and Coker, L. Z.: Phenotypic changes induced by interferon in resting T cells: major enhancement of Ly-6 antigen expression. J. Immunol. 137: 201–210, 1986Google Scholar
  4. Eckhardt, L. A. and Herzenberg, L. A.: Monoclonal antibodies to ThB detect close linkage of Ly-6 and a gene regulating ThB expression. Immunogenetics 11: 275–291, 1980Google Scholar
  5. Gubler, U. and Hoffman, B. J.: A simple and very efficient method for generating cDNA libraries. Gene 25: 263–269, 1983Google Scholar
  6. Hogarth, P. M., Houlden, B. A., Latham, S. E., Sutton, V. R., and McKenzie, I. F. C.: Definition of new alloantigens encoded by genes in the Ly-6 complex. Immunogenetics 20: 57–69, 1984Google Scholar
  7. Hogarth, P. M., McKenzie, I. F. C., Sutton, V. R., Curnow, K. M., Lee, B. K., and Eicher, E. M.: Mapping of the mouse Ly-6, Xp-14, and Gdc-1 loci to chromosome 15. Immunogenetics 25: 21–27, 1987Google Scholar
  8. Houlden, B. A., Hogarth, P. M., and McKenzie, I. F. C.: Interrelationships of the “Ly-6 complex” antigens. Immunogenetics 23: 226–232, 1986Google Scholar
  9. Kimura, S., Tada, N., Liu-Lam, Y., and Hämmerling, U.: Studies of the mouse Ly-6 alloantigen system. II. Complexities of the Ly-6 region. Immunogenetics 20: 47–56, 1984Google Scholar
  10. LeClair, K. P., Palfree, R. G. E., Flood, P. M., Hämmerling, U., and Bothwell, A.: Isolation of a murine Ly-6 cDNA reveals a new multigene family. EMBO J. 5: 3227–3234, 1986Google Scholar
  11. LeClair, K. P., Rabin, M., Nesbitt, M., Pravtcheva, D., Ruddle, F., Palfree, R. G. E., and Bothwell, A.: Murine Ly-6 multigene family is located on chromosome 15. Proc. Natl. Acad. Sci. U.S.A. 84: 1638–1642, 1987Google Scholar
  12. Malek, T. R., Ortega, G., Chan, C., Kroczek, R. A., and Shevach, E. M.: Role of Ly-6 in lymphocyte activation. II. Induction of T cell activation by monoclonal anti-Ly-6 antibodies. J. Exp. Med. 164: 709–722, 1986Google Scholar
  13. Matossian-Rogers, A., Rogers, P., Ledbetter, J. A., and Herzenberg, L. A.: Molecular weight determination of two genetically linked cell surface murine antigens: ThB and Ly-6. Immunogenetics 15: 591–599, 1982Google Scholar
  14. McKenzie, I. F. C., Cherry, M., and Snell, G. D.: Ly-6.2: a new lymphocyte specificity of peripheral T cells. Immunogenetics 5: 25–32, 1977Google Scholar
  15. Ortega, G., Korty, P. E., Shevach, E. M., and Malek, T. R.: Role of Ly-6 in lymphocyte activation. I. Characterization of a monoclonal antibody to a nonpolymorphic Ly-6 specificity. J. Immunol. 137: 3240–3246, 1986Google Scholar
  16. Palfree, R. G. E. and Hämmerling, U.: Biochemical characterization of the routine activated lymphocyte alloantigen Ly-6E.1 controlled by the Ly-6 locus. J. Immunol. 136: 594–600, 1986Google Scholar
  17. Palfree, R. G. E., Dumont, F. J., and Hämmerling, U.: Ly-6A.2 and Ly-6E.1 molecules are antithetical and identical to MALA-1. Immunogenetics 23: 197–207, 1986Google Scholar
  18. Reiser, H., Oettgen, H., Yeh, E. T. H., Terhorst, C., Low, M. G.; Benacerraf, B., and Rock, K. L.: Structural characterization of the TAP molecule: a phosphatidylinositol-linked glycoprotein distinct from the T cell receptor/T3 complex and Thy-1. Cell 47: 365–370, 1986Google Scholar
  19. Sutton, V. R., Mikelson, C. A., Tobias, G. H., Hogarth, P. M., and McKenzie, I. F. C.: Identification of two forms of the Ly-6.2 antigen showing differential expression. Immunogenetics 21: 539–547, 1985Google Scholar
  20. Takei, F.: Biochemical characterization of H9/25, an allospecificity encoded by the Ly-6 region. Immunogenetics 16: 201–208, 1982Google Scholar
  21. Yeh, E. T. H., Reiser, H., Daley, J., and Rock, K. L.: Stimulation of T cells via the TAP molecule, a member in a family of activating proteins encoded in the Ly-6 locus. J. Immunol. 138: 91–97, 1987Google Scholar

Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • Roger G. E. Palfree
    • 1
  • Kenneth P. LeClair
    • 2
  • Alfred Bothwell
    • 2
  • Ulrich Hämmerling
    • 1
  1. 1.Memorial Sloan-Kettering Cancer CenterNew YorkUSA
  2. 2.Howard Hughes Medical Institute, Departments of Pathology and BiologyYale University Medical SchoolNew HavenUSA

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